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EPM.PS membrane filter cartridges for fine, clarifying and biological filtration of liquids



EPM.PS membrane filter cartridges are produced on the basis of the one-layer hydrophilic asymmetric polyethersulphone membrane with the micron ratings of 0.2-0.8 μm. The special pore structure ensures uniform clogging of the membrane and makes it much easier to filter viscous liquids. Increased overall porosity of the membrane combined with high thermal and chemical resistance ensures high flow rate and reliable removal of mechanical particles, bacteria, suspended matters and colloids from liquids in a wide range of ph. Minimal absorption of the polyethersulphone membrane makes EPM.PS the best choice for application in the processes of filtration of albumin containing solutions and biological liquids, especially in biopharmaceutical industry and beverages industry. 



Polyethersulfone (PES) hydrophilic asymmetric membrane.

  • Broad chemical compatibility (pH 1-14).
  • Low protein sorption.
  • Increased thermal resistance ensures (up to 100°C for water).

Asymmetric pore structure and increased overall porosity of the membrane.

  • Excellent filtration characteristics comparable with the best world analogues.
  • High through-put.
  • Increased dirt holding capacity and service life.

High strength of the structure of the cartridge

  • Reliable maintenance of filter integrity under heavy duty operational conditions.
  • Withstands multiple steam sterilization.

Large filtration surface area (pleated)

  • High lifetime and filtration rate at low differential pressure.    

Non-toxic, apyrogenic

  • Guaranteed integrity and efficient operation of the product.
  • Provide full retention of bacteria, bacteriophages and particles in high flow rate processes of liquids filtration.
  • Passed all necessary tests for biological safety, extractability, pyrogene and fiber emission.
  • Provided with necessary quality certificates.

100% integrity control

  • Guaranteed integrity and efficient operation of the product.  

The extremely low adsorption of the polyethersulfone membrane makes EPM.PS ideal for use in filtering protein-containing solutions and biological fluids, especially in the biopharmaceutical and beverage industry.

Main applications

In medicine and biopharmaceutics

  • Fine clarifying filtration of parenteral preparations (LVP) with high or low pH.
  • Fine clarifying filtration of highly viscous media, including ophthalmic solutions.
  •  Filtration of blood preparations, serums, injectable preparations containing protein.
  •  Clarification of large volumes of aqueous, pharmaceutical and biological solutions containing a large number of colloidal particles.
  • Concentrating of solutions containing proteins.
  •  Buffer of buffer solutions.
  • Filtration of galenic preparations.
  • Filtration of process water (washing machines, filtration at points of consumption, non-pyrogenic water for injection, laboratory water purification, recycling water).

In beverage industry

  • Biological filtration of beer in cold filling conditions.
  •  Cold sterilization of beer.
  • Finishing (control) filtration of wines in conditions of "heat" bottling.
  • Polishing filtration of vodkas, cognacs, color LVI.
  • Finishing filtration of mineral waters, low-alcohol and non-alcoholic beverages.
  •  Sterile bottling of still water.
  •  Fine filtration of rinsing water.

In other industries for fine purification of liquid media from particles with size of 0.2 µm or more.

Nominal Dimensions

Filter cartridges

Height (L), mm

Diameter (D), mm

Filter Area (S), m2

125 (5’’)



250 (10’’)



500 (20’’)



750 (30’’)



1000 (40’’)



Capsule filters

Height (L), mm

Diameter (D), mm

Filter Area (S), m2

250 (10’’)



125 (5’’)



60 (2.5’’)



Operational parameters

Maximal differential pressure for cartridges, MPa

0.5 MPa at 20°C, 0.2 MPa at 80°C

Maximal differential pressure for capsules, MPa

0.4 MPa at 20°C, 0.2 MPa at 60°C

Maximal reverse differential pressure, MPa

0.2 MPa at 20°C

Maximal operational temperature, °C

90°C (for cartridges), 60°C (for capsules)

Direct flow wash out

Hot water (up to 95 °C) and chemical agents (pH 3-14)


121°С, 0.12 MPa, 30 min., 80 cycles (cartridges)

121°С, 0.12 MPa, 30 min., 20 cycles (capsules)

132°С, 0.2 MPa, 30 min., 30 cycles (cartridges)

Steam sterilization

Up to 132°С, 0.2 MPa, 30 min., 20 cycles (cartridges)

* For detailed instructions on wash out and sterilization of cartridges and capsules please contact technical specialists of Technofilter. 

Quality and safety

EPM.PS membrane filter cartridges are produced in accordance with the regulatory technical documents on product quality and are certified for use in the filtration processes of biopharmaceutical solutions. All EPM.PS filter cartridges are subjected to wash out from organic and mechanical impurities with high-purity water and to 100% integrity control.  

Wash out, integrity control, drying, final assembly and packaging of membrane filter cartridges is carried out in special clean rooms (ISO class 5, 6 and 7) according to the classification of clean rooms in the pharmaceutical industry.  

EPM.PS membrane filter cartridges undergo tests for bacterial and toxicological safety, materials used in the construction of filters have a minimal amount of extractable components and are approved for contact with intravenous drugs and food. Safety of filter cartridges is determined by a series of sanitary and chemical tests, and toxicology tests in compliance with GOST R ISO 10993.1-99, GOST R ISO 10993.5-99, GOST R ISO 10993.10-00.

Integrity test 

In the course of testing each membrane filter cartridge is integrity tested by the non-destructive physical method of determination of rate of air passing through the water wetted membrane.

Integrity test values of EPM.PS 


Max. diffusion, ml/min

Test pressure, MPa (kgf/cm2)

EPM.PS - 020

≤ 30

0.17 (1.7) at 20°C

EPM.PS - 045

≤ 30

0.14 (1.4) at 20°C

EPM.PS - 065

≤ 30

0.10 (1.0) at 20°C

EPM.PS -  080

≤ 30

0.06 (0.6) at 20°C

*All values are given for the filter cartridges 10” (250 mm) height. To obtain maximum permissible diffusion values for filter cartridges 20” (500 mm) and 30” (750 mm) height the diffusion values for the standard (10”) cartridge should be multiplied by 2 or 3 respectively.  

Bacterial endotoxins (pyrogenicity)

Filtrate samples are examined for bacterial endotoxin (BE) content using the LAL test. BE content – 0.05 EU/ml, the allowable value for water intended for preparation of injection solutions is less than 0.25 EU/ml.

EPM.PS Filter Cartridges ordering information







Micron rating

Adapter code

Cartridge height



020 = 0,2 μm

045 = 0,45 μm

065 = 0,65 μm

080 = 0,80 μm


A (A1), A4, D (D1), B, B (Sl)

100 mm (4”)

125 mm (5”)

250 mm (10”)

500 mm (20”)

750 mm (30”)

1000 mm (40”)

M – medical and biopharmaceutical industry


KFM.PS Capsules ordering information






Micron rating

Connection type

Capsule height


020 = 0,2 μm

045 = 0,45 μm

065 = 0,65 μm

K – sanitary flange connection

P – thread tapered  connection

60 mm (4”)

125 mm (5”)

250 mm (10”)

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